What is Sculptra, and How Does it Work?

Many think Sculptra is a specific type of dermal filler product, but it is not. It is a bio-stimulatory molecule that activates collagen production in the deeper skin tissue, restoring lost tissue support and volume. As we age, our body’s collagen production and content decrease. In fact, by age 45, most people’s skin will have lost 25% of its original collagen content. This shows up on the face as finely wrinkled skin with mid-face sagging or sometimes a thin, gaunt appearance. Exercise enthusiasts may lose collagen at a faster clip. Collagen is responsible for skin structure and strength, a needed scaffold for cells and tissue; it is an essential component of healthy skin and responsible for youthful skin’s vibrant, hydrated appearance.

Before and After Photographs: A woman who has had Sculptra treatments.

Sculptra, also known as Sculptra Aesthetic, is comprised of Poly-L-lactic- acid (PLLA), a biodegradable and biocompatible large synthetic molecule chain that is gradually absorbed by the body. Sculptra has been FDA-approved and used in the United States since 1999. Most recently, in 2022, Sculptra has undergone an FDA re-approval for a better reconstitution method, lending to optimal outcomes with minimal side effects. In clinical studies, 100% of patients showed improvement for up to two years, noting decreased nasolabial folds, increased skin robustness, and an overall refreshed appearance.

The treatment efficacy of Sculptra’s main ingredient, PLLA, was established in a trial of 233 patients who were given up to four treatment sessions with either PLLA or human collagen. The study outcomes reported that patients in the PLLA group had a statistically significant reduction of nasolabial folds compared to their treatment start date. Moreover, the improvement was better than the collagen group at months 3, 6, 9, and 13. Numerous other studies have also supported significant improvements in using PLLA for nasolabial folds, acne scars, facial asymmetry, and other cosmetic indications.